Because the brain region targeted by ET-1 injections expresses A1 receptors at a much higher density than A2A receptors [29], it is likely that the effect of hENT1 expression to increase stroke injury is a direct consequence of reduced ischemia-induced increases in adenosine and decreased A1 receptor activation, relative to Wt mice [28]. The gene discussed is SLC29A1; the disease is Stroke.