The nonimmune mechanisms include the following: (I) the production of reactive oxygen species (ROS) such as peroxynitrites, which cause DNA mutations that contribute to genetic instability and the proliferation of malignant cells [116]; (II) the production of proangiogenic factors such as vascular endothelial growth factor (VEGF), which promote tumor neovascularization [117]; and (III) the production of matrix metalloproteases, which facilitate invasion and metastasis [118]. The gene discussed is VEGFA; the disease is neoplasm.