The study focuses on the effects of these conditions upon (i) ATP synthase, as the impact of metabolic adaptation on the supramolecular organization of ATP synthase has not yet been described; and (ii) Inhibitor Factor 1 (IF1), since it has now been recognized that IF1 function is not limited to its role as the physiological inhibitor of ATP synthase, but that it also constitutes a key component in the metabolic switch of tumor cells [14–16]. This evidence concerns the gene ATP5IF1 and neoplasm.