ATP5IF1 and cancer: Nevertheless, our findings provide some new information that may be useful for comprehension of the oncogenic role of deregulated IF1 expression (mimicked under hyperglycemic conditions), together with the putative oncosuppressor role of mitochondrial biogenesis and ATP synthase supramolecular organization (mimicked under aglycemic conditions) in relation to the understanding of cancer metabolic adaptation and the development of future targeted therapeutic strategies.