Deregulation of multiple elements of the mTOR pathway (PI3K amplification/mutation, PTEN loss of function, AKT overexpression, and S6K1, 4EBP1 and eIF4E overexpression) has been reported in cancer, such as breast, ovarian, renal, colon and head and neck cancers. This evidence concerns the gene EIF4EBP1 and cancer.