GNB3 and cardiovascular disorder: Emerging reports have demonstrated that the C825T polymorphism of GNB3 is associated with different human diseases, such as hypertension [10], cardiovascular diseases [10,11], and ischemic stroke [12] According to a previous study, the C825T polymorphism of GNB3, T-homozygosity was found to be significantly more common among female myocardial infarction (MI) fatalities than the female control group (24% versus 7%; Relative Risk 2.29).