TNF and hypertensive disorder: According to previous TNF-α-308G/A SNP studies performed in Taiwanese cohorts, the A homozygous carriage is seldom detected, only ranging from 0.37%–1.25%, and it is not associated with hypertension and type II DM [30,31] (The lower frequency obtained in the present study was 4.13%, which might also reflect the nature of genetically predisposing factors.