Excluding the influence on blood pressure control, many studies examined the potential association between GNB3 C825T polymorphism and several other phenotypes of clinic traits, such as obesity [18,32,33], atherosclerosis [11,34], myocardial infarction [35], radial artery hypertrophy [36], and diabetes [37]. Here, GNB3 is linked to obesity due to melanocortin 4 receptor deficiency.