In the present study we investigated whether olmesartan decreased the impairment of endothelial cells induced by ox-LDL by exerting its effects on LOX-1 both in vitro and in vivo. Our findings suggested that olmesartan might play a role in the inhibition of endothelial cell injuries induced by ox-LDL and thereafter in the suppression of atherosclerosis through down regulation of LOX-1 expression. Here, OLR1 is linked to atherosclerosis.