The reintroduction of miR-148a and miR-34b/c in cancer cells with epigenetic inactivation inhibited cell motility, reduced tumor growth, and inhibited metastasis formation in xenograft models, with an associated down-regulation of the miRNA oncogenic target genes, such as C-MYC, E2F3, CDK6, and TGIF2. The gene discussed is MYC; the disease is neoplasm.