Local AngII (via AT1 receptors) activates NADPH-dependent oxidases (Garrido and Griendling 2009; Touyz 2004), which are a major source of superoxide and are upregulated in major aging-related diseases such as hypertension, diabetes and atherosclerosis (Benigni et al. 2009; Griendling et al. 2000; Münzel and Keany 2001). Here, AGT is linked to hypertensive disorder.