SPARC and neoplasm: For example, Abraxane® (paclitaxel protein-bound particles for injectable suspension (albumin bound), also known as nab®-paclitaxel or ABI-007, Abraxis BioScience/Celgene; Fig. 2) can achieve rapid tumor penetration and enhanced accumulation by utilizing the albumin transport pathways, including gp60 albumin receptor and caveolae-mediated endothelial transcytosis (Fig. 3) across endothelium of the blood-tumor barrier and potential interaction with albumin binding proteins (e.g., secreted protein, acidic and rich in cysteine (SPARC)) in the tumor interstitium (10).