For example, in healthy-adults during the winter, low serum 25(OH)D concentrations corresponded with increased IFN-γ and IL-10 production [35], while supplemental vitamin D (cholecalciferol) increased IL-10 in congestive heart failure patients [36] but was ineffective at modulating IFN-γ, IL-5 or IL-10 in overweight or obese subjects [37]. Here, IL10 is linked to congestive heart failure.