We have recently shown that the number of lifetime ovulatory cycles does not influence breast cancer risk in women with BRCA1 or BRCA2 mutations (JK, JL, HTL, C K-S, SN, RD, WDF, PG, NT, PA, LS, Beth Karlan, AE, CE, Jeffrey Weitzel, DMG, JB, Dana Zakalik, CS, Taya Fallen, OG, TH, PS, SAN, Oophorectomy after Menopause and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers, submitted). The gene discussed is BRCA2; the disease is breast carcinoma.