CRP and rheumatoid arthritis: Despite these therapies, his RA disease activity remained high (tender and swollen joints at the knees and ankles; patient global assessment score, 48/100 mm; C-reactive protein (CRP), 3.37 mg/dL; erythrocyte sedimentation rate (ESR), 48 mm/hour; matrix metalloproteinase-3, 1531 ng/mL; Disease Activity Score 28-ESR, 4.57).