Another CD74-dependent anti-apoptotic pathway promotes B-CLL cell growth and survival by activating p65 (a member of the NF-κB family), upregulating expression of the transactivation isoforms of p63 (TAp63), and inducing Bcl-2 expression and interleukin-8 (IL-8) secretion [2,11,12]. Here, CXCL8 is linked to B-cell chronic lymphocytic leukemia.