PLOD1 and Testicular atrophy: Although dose, duration and species differ, there exists some evidence in adult male rats [23], adult monkeys [21] adult and agonadal juvenile monkeys [22] and prepubertal male rats [35] that continuous administration of kisspeptin desensitizes kiss1r which eventually results in decreased LH secretion and testicular degeneration, while in females irrespective of dose, duration and species the results are completely different compared to males, leading to an early maturation of reproductive axis.