The variable region glycosylation levels of plasma total IgG of 20 normal controls, 10 patients with anti-MPO antibodies (no. 1-10), 6 patients with both anti-MPO antibodies and anti-GBM antibodies (no.11-16), 6 patients with anti-GBM antibodies (no.17-22), and 5 patients with anti-PR3 antibodies (no. 23-27) was 0.253 ± 0.102, 0.256 ± 0.096, 0.215 ± 0.060, 0.238 ± 0.050 and 0.245 ± 0.088, respectively [expressed by the absorbance value at 405 nm (A405)]. The gene discussed is MPO; the disease is glioblastoma.