When combined with PH II-7 (0.5 μM), the efficacy of ADM against MDR cancer cell lines (K562/A02, MCF7/ADR) was greatly augmented, the same combinatorial effect was also observed with another chemotherapy agent Vincristine (VCR) which, like ADM, is also a substrate of P-gp (Fig. 2C). The gene discussed is PGP; the disease is cancer.