LDLR and atherosclerosis: Using a series of subcongenic mouse strains, Kuo et al. recently linked this genomic region to decreased p16INK4a and p19ARF (the murine variant of p14ARF) gene expression in macrophages and monocytes and to atherosclerosis formation in the atherosclerosis-prone low density lipoprotein receptor-deficient (ldlr−/−) background [10].