Changes in expression of other genes that have been associated with neurodegeneration include: 1) cerebellar degeneration-related 2 (Cdr2) which was down-regulated in the HP (although not in the CB); 2) reduced expression in transcription factors associated with neurogenetic diseases (e.g. Fos, JunB) was seen in the CB; and 3) decreased expression of glycine amidinotransferase (Gatm) in the BS, a gene associated with mental retardation [34]. This evidence concerns the gene CDR2 and hereditary neurological disease.