Moreover, these data confirm the observations from the previous studies in which the relationship between the type 2 diabetes risk alleles in KCNQ1 and reduced levels of various measures of insulin secretion have been reported [17], [18], [22], [24], and hence, supports the hypothesis on a potential link between KCNQ1 and impaired beta-cell function [2], [3], [17], [18], [22], [23], [24], [25], [26]. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.