To investigate potential mechanisms by which the variants in KCNQ1 may contribute to type 2 diabetes susceptibility, we used regression analysis to examine the effects of KCNQ1 genotypes on first- and second-phase of glucose stimulated insulin secretion, insulin sensitivity index (ISI) and disposition index (DI) in a sample of non-diabetic individuals in whom hyperglycaemic clamp was performed (Table 3). This evidence concerns the gene INS and type 2 diabetes mellitus.