The fact that NLRP3 (Q705K)/CARD-8 (C10X) polymorphisms are quite prevalent in the healthy population, taken together with the heterogeneity of these diseases, as well as of the symptoms of the patients of this study, suggests these polymorphisms to act as susceptibility factors that in conjunction with an environmental cue, such as an infection or by additional genetic variations, predispose for enhanced inflammation. This evidence concerns the gene NLRP3 and infection.