In addition to these novel findings, further studies should provide a greater understanding of the inherent complexities in the roles of PI3-K in the control of cell survival and apoptosis/anoikis not only within the normal physiological context of the epithelium of the gut, but as well within the physiopathological context of gastrointestinal disorders—such as CRC. Here, PIK3CD is linked to colorectal carcinoma.