While the status of p55γ in CRC tumors and/or cells remains unknown, such findings in CRC altogether stand in stark contrast to our own in normal, non-transformed and non-immortalized HIEC cells—therefore underlying the need to investigate fully the expression, regulation and roles of PI3-K isoforms under the normal physiological context, in order to achieve a better comprehension of the aberrant expression and/or deregulation of these isoforms in cancer and cancer cell lines [16, 18–22, 38, 50, 51]. The gene discussed is PIK3CD; the disease is cancer.