By univariate analysis, we found that resected PR (P = 0.005), prehepatectomy AFP > 400 ng/dl (P = 0.008), HCC size > 50 mm (P = 0.023), higher Edmonson grade (P = 0.033), serosal involvement (P = 0.002), interval between hepatectomy and PR > 6 months (P = 0.001), and AFP at detection of PR > 200 ng/dl (P = 0.008) were significant factors. This evidence concerns the gene AFP and hepatocellular carcinoma.