The JAK-STAT pathway can be activated by IFN-γ and IL-6, along with several other cytokines, and there may be an interaction between these biomarkers and rs4132670: individuals that possess the rs4132670 T allele may have higher levels of STAT1-STAT3 binding to the TCF7L2 enhancer, leading to increased expression levels, which will be exacerbated under chronic inflammatory stimuli, potentially leading to higher T2D in these individuals. The gene discussed is STAT3; the disease is type 2 diabetes mellitus.