IL6 and type 2 diabetes mellitus: The JAK-STAT pathway can be activated by IFN-γ and IL-6, along with several other cytokines, and there may be an interaction between these biomarkers and rs4132670: individuals that possess the rs4132670 T allele may have higher levels of STAT1-STAT3 binding to the TCF7L2 enhancer, leading to increased expression levels, which will be exacerbated under chronic inflammatory stimuli, potentially leading to higher T2D in these individuals.