Thus, it is intriguing to speculate that restoring IGFBP3 expression and/or use of demethylating drugs could contribute to new therapeutic strategies for HB, especially with the existence of additional epigenetically silenced genes in this tumor type, such as HHIP, RASSF1, SOCS1, APC and CASP8 [40]. Here, RASSF1 is linked to neoplasm.