Correspondingly, TIA1 is also upregulated in the majority of HB cases (Figure 1E) and is inversely correlated with the expression of IGFBP3 (Figure 1F), although at a low level (rho = -0.3295) Altogether, these data suggest that the downregulation of IGFBP3 might significantly contribute to the activation of the IGF signaling cascade by sustaining the IGF2-induced stimulation in HB. Here, IGF2 is linked to hemoglobin measurement.