By analyzing clinicopathological features, such as gender, age at diagnosis, tumor differentiation, metastatic disease, outcome, multifocality, and vascular invasion (Table 1), we observed that IGFBP3 promoter methylation was significantly associated with metastases and invasion into large hepatic veins, two high-risk parameters for HB patients. This evidence concerns the gene IGFBP3 and metastatic neoplasm.