MTOR and malignant colon neoplasm: For example, genetic aberrations of the catalytic subunit of the phosphatidylinositol 3-kinase (PI3K), an upstream effector of mTORC1 and mTORC2, are frequent in colon cancer [12,13].Moreover, the inhibition of mTOR signals by allosteric inhibitors such as rapamycin or small interfering RNA has been shown to reduce colon cancer growth in different experimental settings [10,11,14,15].