For CRP and Krenn classification, a statistically significant difference was observed between patients whose tissues featured histologically identified fulminating inflammation in the form of lymphofollicles and synovial palisading cells (high-RA group: H) and those whose tissues featured mild inflammation (low-RA group: L) (p < 0.008; t-test). The gene discussed is CRP; the disease is rheumatoid arthritis.