MT-ND1 and Leber hereditary optic neuropathy: Three primary mutations (m.3460G > A in the MT-ND1 gene, m.11778G > A in the MT-ND4 gene, and m.14484T > C in the MT-ND6 gene) accounted for the etiology of more than 95% LHON patients, whereas the remaining 5% cases was caused by rare mutations and/or unclear factors [1-3].