MT-ND5 and Leber hereditary optic neuropathy: Similarly, two private variants were found in patient Le1330, which were located in the MT-ND1 and MT-ND5 genes (Table 1), further supported our previous claim that the MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations [15].