PRNP and scrapie: Compared with PrPres in the mice brains infected by the individual parent mouse-adapted strains in Western blot with PrP-specific mAb 1E4, in which the monoglycosyl PrPres were predominant (Figure 4B), the diglycosyl PrPres in hamsters brains of agents 139A and ME7 were predominant (Figure 4A), suggesting that mouse-adapted scrapie strains may change their PrPSc molecular profiles after replicating in hamsters brains.