Specifically, variants associated with CHD (and AAA) disrupt binding of the transcription factor STAT1, which results in altered expression CDKN2A and CDKN2B, MTAP (methylthioadenosine phosphorylase, an enzyme that plays a major role in polyamine metabolism), and IFNA21 (interferon alpha-21). The gene discussed is MTAP; the disease is coronary artery disorder.