Hyaluronan is often bound to CD44 isoforms, which are ubiquitous, abundant, and functionally important cell surface receptors [18] in coordinating intracellular signaling pathways (e.g., Ca2+ mobilization [19], Rho signaling [20], PI3-kinase/AKT activation [21], NHE1-mediated cellular acidification [22], transcriptional upregulation, and cytoskeletal function [23]) and generating the concomitant onset of tumor cell activities (e.g., tumor cell adhesion, growth, survival, migration, and invasion) and tumor progression. The gene discussed is RHO; the disease is neoplasm.