The anti-gene anti-IGF-I therapy, giving a strong immune antitumour response in different comparatively studied tumour diseases, presents all characteristics of cell immunotherapy (CD8+and CD28+ expression in T lymphocytes, and MHC-I and B7 expression in “vaccine” cells) including apoptotic phenomenon [4, 15, 45, 53]. The gene discussed is CD28; the disease is neoplasm.