TGFB1 and neoplasm: Activation of the PI3K/AKT/GWK3/GS pathway is mediated by some tyrosine kinase receptors, under the control of several growth factors and cytokines as EGF, PDGF, VEGF, TGFbeta, CSF, and especially IGF-I, whose receptor, IGF-I-R, plays a principal role in the tumour growth process [4, 6, 34].