The principal goal of this work—Phase I gene therapy of glioblastoma—was to establish the criteria of methodology for clinical trial based on principal results of previously described studies—the immune antitumour phenomenon observed in the antisense anti-IGF-I treatment of rat and human gliomas, and signaled by the increase of CTL CD8+ in the tumour tissue as well as in peripheral blood lymphocytes [4]. Here, CD8A is linked to central nervous system cancer.