IGF1 and cancer: In our experimental clinical trial, to avoid this effect of “contamination” increased by numerous passages, the primary cancers cells and transfected cancer cells were systematically cloned after every passage to obtain in vitro, in the first case 100% IGF-I(+), MHC-I(−), and in the second case 100% IGF-I(−), MHC-I(+) expression.