In addition, the expression of other positive regulators of the Wnt pathway (including Dvl-3, FRAT-1, Pygo-2, Tcf4, and Lef-1) [38, 63, 64] and of Wnt target genes (namely the regulators of cell proliferation Cyclin D1 and c-myc) [38, 62] also increases in high-grade astrocytomas and GBM (see Figure 1). The gene discussed is MYC; the disease is glioblastoma.