Given the higher mortality rate of ICU patients with sepsis and AKI, we decided to investigate the possible correlation between serum biochemical markers of organ damage, such as neutrophil gelatinase-associated lipocalin (NGAL), advanced oxidation protein products (AOPP), and brain natriuretic peptide (BNP) and endotoxin activity in ICU septic patients. This evidence concerns the gene NPPB and acute kidney injury.