Doxorubicin and oxaliplatin can also induce release of ATP by tumor cells, which triggers purinergic P2RX7 receptors on dendritic cells (DCs) to activate the NOD-like receptor family, pyrin-domain-containing protein 3-dependent caspase-1 activation complex, namely, the NLRP3 inflammasome, which ultimately leads to IL-1β-dependent adaptive immunity [15]. The gene discussed is IL1B; the disease is neoplasm.