T cells expressing MA3/DP4 TCR (but not Mock) were able to respond to MZ2-MEL43 melanoma cells only when target cells were preloaded with MA3 16 mer peptide; this demonstrates that these melanoma cells can be sensitized to peptide-specific T-cell functions (i.e., cytotoxicity: data not shown; production of IFNγ and TNFα: Figure 6(b)). This evidence concerns the gene TNF and melanoma.