In this light, the different prognostic value of FOXP3+ Tregs in GC-type DLBCL where their presence is related with a positive prognostic influence and non-GC DLBCL where, by contrast, an increase of FOXP3+ Tregs directly correlates with an adverse outcome, could be at least partially explained by the marked inflammatory environment engendered in the latter by the abundancy of IL-6- and TNF-producing Ms and MCs [34–36]; this could inhibit the function of Tregs which, in turn, could even boost inflammation favouring Th17 generation [28]. This evidence concerns the gene TNF and diffuse large B-cell lymphoma.