Researchers found specific genes such as AZIN1, TLR4, CXCL9, CXCL10, CTGF, ITIH1, SERPINF2, TTR, PDGF, TGF-β1, collagens COL1-A1, TNFα, interleukin, ADAMTS, MMPs, TIMPs, LAMB1, LAMC1, Cadherin, CD44, ICAM1, ITGA, APO and CYP2C8 that showed deregulation during liver fibrosis and may be used to access liver fibrosis and cirrhosis [11-28]. This evidence concerns the gene COL1A1 and Hepatic fibrosis.