Our previous demonstration of Src/ezrin co-operativity [33], and the required Y477 phosphorylation of ezrin by Src in HGF-induced scattering of epithelial cells [6], prompted us to examine the role of Y477 ezrin in primary tumor growth, local invasion and metastasis in an in vivo model of malignant breast cancer. This evidence concerns the gene HGF and neoplasm.