Meanwhile in 2009, IDH1 mutation was reported in a subset of AML patients lacking specific chromosomal aberrations [5] and in 2010, IDH2 mutation was identified in AML, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN) [15-17]. The gene discussed is IDH2; the disease is myeloproliferative neoplasm.