YWHAQ and Creutzfeldt Jacob disease: With a sensitivity of 100% and specificity of 63.6% for cAMP and a sensitivity of 66.7% and specificity of 100% for cGMP they do not reach the potency of other CJD biomarkers, e.g. tau protein, 14-3-3 protein or S-100 protein [20], [45], [46].