Fig. 5 shows a correlation analysis of cAMP and cGMP with tau protein. There was a weak but significant negative correlation (p = 0.04) between cAMP and tau protein concentrations in the CSF of CJD patients (Fig. 5A). Concentrations of cGMP did not correlate with tau protein (Fig. 5B). The gene discussed is MAPT; the disease is Creutzfeldt Jacob disease.