RYR2 and myocardial ischemia: Although 1134 potential targets of miR-376b-5p were predicted, only a few of them have been reported to be involved in myocardial ischemia, including insulin-like growth factor 2 mRNA binding protein 2 [24], [25], ryanodine receptor 2 [26]–[28] and BDNF [29]–[35].