IFNB1 and cancer: To test whether elevated MHC I expression through IFN-β secretion/signaling is a general phenomenon induced by cancer chemotherapeutics, ZR-75-1 cells were treated with etoposide (a topoisomerase II inhibitor), cisplatin (a DNA damaging agent), paclitaxel (a microtubule stabilizer) and vinblastine (a microtubule destabilizer).