Single round transduction with HIV-fLuc resulted in an additional 4.7-fold reduction of luciferase reporter activity when compared with LEDGF KO cells (Figure S5F), whereas HIVNL4.3 replication was affected 10-fold at day 8 post infection when comparing LEDGF/p75 KO and LEDGF/p75 KO HRP-2 KD cells (compare Figure S5D with S5E, condition without compounds). The gene discussed is PSIP1; the disease is infection.