As for WT (KN99α) C. neoformans, the acapsular strain (cap59D), which also induced cell cycle alteration and aneuploidy (Figure 4B, C), led upon infection to decreased levels of MAD2, cyclin-D1 and Skp2 (Figure 8D), in contrast to serotype D strain (JEC21), which had no impact on the levels of these proteins as expected. This evidence concerns the gene CCND1 and infection.