The results described above prove that enalaprilat can block the nuclear translocation of p-p38MAPK and its phosphorylation induced by Ang II and reduce TGF-β1 generation to resist CFb proliferation through diminishing ROS generation, thereby reverse the occurrence of myocardial fibrosis, implying that enalaprilat inhibits CFb proliferation and extracellular matrix deposition through blocking ROS-p38MAPK-TGF-β1 signaling transduction pathways. Here, AGT is linked to Myocardial fibrosis.