First discovered in 1891 from a mixed extract of Streptococcus pyogenes and Serratia marcescens bacteria [101] and later characterised with tumor-regression activity [102], TNF-α belongs to a superfamily of ligand/receptor proteins called the tumor necrosis factor/tumor necrosis factor receptor superfamily proteins (TNF/TNFR SFP). This evidence concerns the gene TNF and neoplasm.