Albeit the ubiquity of TNF-α following experimental models of spinal cord injury, randomised controlled clinical trials of infliximab (antibody to TNF-α) and etanercept (recombinant TNFR2) have not demonstrated benefits for patients with discogenic sciatica [121-124], which thwarted further research of anti-TNF-α treatment for other types of neuropathic pain. Here, TNF is linked to Sciatica.