The authors found that anti-Ro52/TRIM21 antibodies were commonly found in the presence of other autoantibodies (in particular, Sm, chromatin, Jo-1, and CENP-B) and that 73% of patients had an autoimmune disease (in particular, polymyositis/dermatomyositis, SjS, SSc, and autoimmune hepatitis). This evidence concerns the gene TRIM21 and autoimmune disease.