Experimental work with animal models of cerebral ischemia [5,18,19] and acute ischemic stroke patients [20] indicates that the onset of the ischemic insult is followed by an increase in the expression of TWEAK and Fn14 in the ischemic tissue and serum, which has been deemed to have a negative impact on the final neurological outcome. Here, TNFSF12 is linked to brain ischemia.