Thus, the primary objective of the present study was to evaluate the relationship between pGDM representing a special cohort of early prediabetes in females and the risk for presence of fatty liver, estimated by the FLI, with special regard to insulin resistence as well as the association with prothrombotic and proinflammatory factors as well as the free-fatty-acid (FFA) kinetics during an oral-glucose-tolerance-test (OGTT) at 3 to 6 month after index pregnancy. This evidence concerns the gene INS and fatty liver disease.