Finally, we find several deregulated canonical pathways which may point towards the presence of altered insulin signaling and oxidative stress (Inositol Phosphate Metabolism, Insulin Receptor Signaling, NRF2-mediated oxidative stress response, IGF-1 Signaling, and Hypoxia Signaling in the Cardiovascular System)(see table 3), pointing towards alterations in glucose metabolism in schizophrenia, as have been demonstrated to exist not only secondary to the use of antipsychotics, but also in antipsychotic-naïve patients [25], [51]–[53]. Here, INSR is linked to schizophrenia.